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2 mg Clonazepam. Manufactured by Roche & TEVA
Klonopin (clonazepam) is a benzodiazepine officially indicated for management of seizure disorders and panic disorder. The use of a drug for its approved indications is called its labeled use. In clinical practice, however, physicians often prescribe medications for unlabeled (“off-label”) uses when published clinical studies, case reports, or their own clinical experiences support the efficacy and safety of those treatments. Physicians may use Klonopin outside its approved indications to treat social anxiety disorder, posttraumatic stress disorder, agitation in acute psychosis and mania, and premenstrual syndrome. As with other benzodiazepines, Klonopin is associated with dependence and abuse and is regulated as a controlled substance by state and federal laws. Klonopin’s effectiveness for treating anxiety may be explained by its pharmacological action in the brain at specific receptor sites. Receptors are specific sites on the nerve cell membrane that receive a signal from a neurochemical called the neurotransmitter. Once a neurotransmitter locks in on the receptor, the neurochemical signal is changed to an electrical or another chemical signal and travels down the neuron. The receptor sites in which benzodiazepines elicit their action are found in various regions of the brain, and the specific receptors are also known as benzodiazepine receptors. The coupled reaction of benzodiazepines to the receptors facilitates the inhibitory action of the neurotransmitter γ-aminobutyric acid (GABA) in that region of the brain. Benzodiazepines’ action on GABA receptors appears to produce their anxiolytic, sedative, and anticonvulsant actions. Klonopin, for example, is an effective anxiolytic, hypnotic, and antiseizure medication.